KMID : 0360220090500030390
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Journal of the Korean Ophthalmological Society 2009 Volume.50 No. 3 p.390 ~ p.398
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Photodynamic Therapy for Chronic Central Serous Chorioretinopathy: Multicenter Study of 65 Cases
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Oh Jae-Ryung
Kwon Oh-Woong Kim Min-Ho Kim Jong-In Kim Ha-Kyoung Kim Hyung-Chan Nam Dong-Heun Park Kyu-Hyung Sohn Joon-Hong Oum Boo-Sup Yu Seung-Young Yoon Young-Hee Yoon Ill-Han Yoon Hee-Sung Lee Jae-Heung Lee Jeong-Hee Lee Ji-Eun Chang Woo-Hyok Cho Sung-Won Chin Hee-Seung Huh Kuhl Hyung Woo Kwak
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Abstract
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Purpose: To determine the effect of photodynamic therapy (PDT) on patients with chronic central serous chorioretinopahty (CSC).
Methods: This was a retrospective multicenter study. We collected demographic and ophthalmic data for patients with chronic CSC who were treated with PDT from 16 institutions in Korea. The best corrected visual acuity (BCVA), ophthalmoscopic finding and optical coherence tomography at baseline and follow-up visits were compared longitudinally.
Results: Sixty-five eyes of 65 patients were recruited. Males (51 patients, 78.5%) outnumbered females (14 patients, 21.5%). The mean age was 46.4¡¾10.0 years of age (28~69). By 1 month, mean BCVA improved from 0.47 to 0.37 (logarithm of the minimum angle of resolution) (P <0.01). This BCVA increased throughout 6 months. Subretinal fluid resolved partially or completely in 89.1% of the patients. Central macular thickness (CMT) decreased from 303.4 to 168.7 ¥ìm. The amount of change in CMT after PDT was correlated to the female sex and prePDT CMT. At 3 months after PDT, the amount of change in BCVA was significantly related to that of change of CMT (p <0.05). Adverse events were reported in 4 cases, however, most were mild.
Conclusions: PDT was effective and safe for treating chronic CSC.
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KEYWORD
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BCVA, Chronic CSC, CMT, PDT
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