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KMID : 0360220090500030390
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Journal of the Korean Ophthalmological Society
2009 Volume.50 No. 3 p.390 ~ p.398
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Photodynamic Therapy for Chronic Central Serous Chorioretinopathy: Multicenter Study of 65 Cases
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Oh Jae-Ryung
Kwon Oh-Woong
Kim Min-Ho
Kim Jong-In
Kim Ha-Kyoung
Kim Hyung-Chan
Nam Dong-Heun
Park Kyu-Hyung
Sohn Joon-Hong
Oum Boo-Sup
Yu Seung-Young
Yoon Young-Hee
Yoon Ill-Han
Yoon Hee-Sung
Lee Jae-Heung
Lee Jeong-Hee
Lee Ji-Eun
Chang Woo-Hyok
Cho Sung-Won
Chin Hee-Seung
Huh Kuhl
Hyung Woo Kwak
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Abstract
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Purpose: To determine the effect of photodynamic therapy (PDT) on patients with chronic central serous chorioretinopahty (CSC).
Methods: This was a retrospective multicenter study. We collected demographic and ophthalmic data for patients with chronic CSC who were treated with PDT from 16 institutions in Korea. The best corrected visual acuity (BCVA), ophthalmoscopic finding and optical coherence tomography at baseline and follow-up visits were compared longitudinally.
Results: Sixty-five eyes of 65 patients were recruited. Males (51 patients, 78.5%) outnumbered females (14 patients, 21.5%). The mean age was 46.4±10.0 years of age (28~69). By 1 month, mean BCVA improved from 0.47 to 0.37 (logarithm of the minimum angle of resolution) (P <0.01). This BCVA increased throughout 6 months. Subretinal fluid resolved partially or completely in 89.1% of the patients. Central macular thickness (CMT) decreased from 303.4 to 168.7 μm. The amount of change in CMT after PDT was correlated to the female sex and prePDT CMT. At 3 months after PDT, the amount of change in BCVA was significantly related to that of change of CMT (p <0.05). Adverse events were reported in 4 cases, however, most were mild.
Conclusions: PDT was effective and safe for treating chronic CSC.
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KEYWORD
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BCVA, Chronic CSC, CMT, PDT
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